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Article

Characterization of pathogenic missense mutations in nuclear encoded mitochondrial dynamin -1 like protein.

Mutation research - 1 Jan 2026

Sivakumar Kaniha, Sidhic Nihala, Subbiah Usha, Mookkandi Sudhan

Abstract excerpt

BACKGROUND: The DNM1L gene encodes the dynamin-related protein, Drp1, essential for mitochondrial fission. Impaired mitochondrial division contributes to cardiovascular, neurodegenerative, and metabolic disorders. This study aimed to identify and analyse deleterious nonsynonymous single nucleotide polymorphisms (nsSNPs) in DNM1L that may impair protein function. METHODS: An integrated in silico strategy combining...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41785731
DOI: 10.1016/j.mrfmmm.2026.111928

Genes

DNM1L

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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