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Article

Glutathione transferases in the bioactivation of azathioprine.

Advances in cancer research - 1 Jan 2014

Modén Olof, Mannervik Bengt

Abstract excerpt

The prodrug azathioprine is primarily used for maintaining remission in inflammatory bowel disease, but approximately 30% of the patients suffer adverse side effects. The prodrug is activated by glutathione conjugation and release of 6-mercaptopurine, a reaction most efficiently catalyzed by glutathione transferase (GST) A2-2. Among five genotypes of GST A2-2, the variant A2*E has threefold-fourfold higher...

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Identifiers

PMID: 24974183
DOI: 10.1016/B978-0-12-420117-0.00006-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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