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Article

SUMO3 modification accelerates the aggregation of ALS-linked SOD1 mutants.

PloS one - 1 Jan 2014

Niikura Takako, Kita Yoshiko, Abe Yoichiro

Abstract excerpt

Mutations in superoxide dismutase 1 (SOD1) are a major cause of familial amyotrophic lateral sclerosis (ALS), whereby the mutant proteins misfold and aggregate to form intracellular inclusions. We report that both small ubiquitin-like modifier (SUMO) 1 and SUMO2/3 modify ALS-linked SOD1 mutant proteins at lysine 75 in a motoneuronal cell line, the cell type affected in ALS. In these cells, SUMO1 modification...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24971881
DOI: 10.1371/journal.pone.0101080
PMCID: PMC4074151

Genes

SOD1
SUMO3
SUMO1
SUMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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