Article
SUMO-1 modification increases human SOD1 stability and aggregation.
Biochemical and biophysical research communications - 25 Aug 2006
Fei Erkang, Jia Nali, Yan Ming, Ying Zheng, Sun Qiang, Wang Hongfeng, Zhang Tao, Ma Xiaochuan, Ding Husheng, Yao Xuebiao, Shi Yunyu, Wang Guanghui
Abstract excerpt
The mutations in the gene encoding copper-zinc superoxide dismutase (SOD1) cause approximately 20% cases of familial amyotrophic lateral sclerosis (FALS), characterized by selective loss of motor neurons. Mutant SOD1 forms inclusions in tissues from FALS patients. However, the precise mechanism of the accumulation of mutant SOD1 remains unclear. Here we show that human SOD1 is a substrate modified by SUMO-1. A...
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