Article
SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.
PloS one - 1 Jan 2013
Zhou Ya-Fang, Liao Shu-Sheng, Luo Ying-Ying, Tang Jian-Guang, Wang Jun-Ling, Lei Li-Fang, Chi Jing-Wei, Du Juan, Jiang Hong, Xia Kun, Tang Bei-Sha, Shen Lu
Abstract excerpt
Post-translational modification by SUMO was proposed to modulate the pathogenesis of several neurodegenerative diseases. Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disease caused by polyQ-expanded ataxin-3. We have previously shown that ataxin-3 was a new target of SUMOylation in vitro and in vivo. Here we identified that the major SUMO-1 binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.