Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma.

Investigative ophthalmology & visual science - 26 Jun 2014

Ewens Kathryn G, Kanetsky Peter A, Richards-Yutz Jennifer, Purrazzella Juliana, Shields Carol L, Ganguly Tapan, Ganguly Arupa

Abstract excerpt

PURPOSE: Somatic mutations in GNAQ, GNA11, SF3B1, EIF1AX, and BAP1 have been identified in uveal melanoma (UM). The aim of this study was to determine whether mutations in these genes in primary tumors were associated with metastases in individuals diagnosed with UM. METHODS: A total of 63 UM cases who developed a metastasis within 48 months of primary treatment and 53 UM controls who were metastasis-free over a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 3
Share to GTP-Binding Protein alpha Subunits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Ribonucleoprotein, U2 Small Nuclear

Share to RNA Splicing Factors

Share to Ubiquitin Thiolesterase

Share to Uveal Melanoma

Share to Uveal Neoplasms

Source

Identifiers

PMID: 24970262
DOI: 10.1167/iovs.14-14550

Genes

BAP1
GNA11
GNAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma.PMID 24970262Read ↗

Monosomy 3 status of uveal melanoma metastases is associated with rapidly progressive tumors and short survival.Semantic proximity Read ↗

Genetics and RNA Regulation of Uveal MelanomaSemantic proximity Read ↗

Uveal Melanomas with SF3B1 Mutations: A Distinct Subclass Associated with Late-Onset Metastases.Semantic proximity Read ↗

Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma.Semantic proximity Read ↗

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3.Semantic proximity Read ↗

New concepts in the molecular understanding of uveal melanomaSemantic proximity Read ↗

Correlation between BAP1 Localization, Driver Mutations, and Patient Survival in Uveal MelanomaSemantic proximity Read ↗

Genomic Profiling of Metastatic Uveal Melanoma Shows Frequent Coexisting BAP1 or SF3B1 and GNAQ/GNA11 Mutations and Correlation With Prognosis.Semantic proximity Read ↗

Metastatic Disease in Polyploid Uveal Melanoma Patients Is Associated With BAP1 Mutations.Semantic proximity Read ↗

Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes.Semantic proximity Read ↗

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.Semantic proximity Read ↗

Genetic landscape of uveal melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.