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Article

Monosomy 3 status of uveal melanoma metastases is associated with rapidly progressive tumors and short survival.

Experimental eye research - 1 Jul 2012

Abdel-Rahman Mohamed H, Cebulla Colleen M, Verma Vishal, Christopher Benjamin N, Carson William E, Olencki Thomas, Davidorf Frederick H

Abstract excerpt

The aim of the study was to investigate the molecular genetics of uveal melanoma (UM) metastases and correlate it with disease progression. Twelve pathologically confirmed UM metastases from 11 patients were included. Molecular genetic alterations in chromosomes 3 (including the BAP1 region), 8q, 6p, and 1p were investigated by microsatellite genotyping. Mutations in codon 209 of GNAQ and GNA11 genes were studied...

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Source

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Identifiers

PMID: 22569040
DOI: 10.1016/j.exer.2012.04.010
PMCID: PMC4294816

Genes

GNA11
GNAQ
BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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