Article
Progressive chromogenic anti-factor Xa assay and its use in the classification of antithrombin deficiencies.
Clinical chemistry and laboratory medicine - 1 Dec 2014
Kovács Bettina, Bereczky Zsuzsanna, Selmeczi Anna, Gindele Réka, Oláh Zsolt, Kerényi Adrienne, Boda Zoltán, Muszbek László
Abstract excerpt
BACKGROUND: Antithrombin (AT) is a slow-acting progressive inhibitor of activated clotting factors, particularly thrombin and activated factor X (FXa). However, the presence of heparin or heparan sulfate accelerates its effect by several magnitudes. AT deficiency, a severe thrombophilia, is classified as type I (quantitative) and type II (qualitative) deficiency. In the latter case mutations may influence the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.