Article
Genetic control of susceptibility to mycobacterial infections.
Reviews of infectious diseases - 1 Jan 2000
Skamene E
Abstract excerpt
Susceptibility of mice to the establishment of infection after exposure to mycobacteria is controlled by a single, dominant, autosomal gene: the Bcg gene. It is located on the centromeric portion of chromosome 1 within a linkage group that shows structural homology with a conserved region of human chromosome 2. The Bcg gene regulates directly the process of T cell-independent macrophage activation for...
Topics
- Animals
- Disease Models, Animal
- Disease Susceptibility
- Genes, MHC Class II
- Humans
- Mice
- Mycobacterium Infections
- Phenotype
- Tuberculosis