Article
Population and molecular genetics of susceptibility to tuberculosis.
Clinical and investigative medicine. Medecine clinique et experimentale - 1 Apr 1991
Skamene E
Abstract excerpt
Genetic influences on the course of mycobacterial infections during epidemics and in the endemic areas have always been suspected, but the precise nature of such genetic control and of the inherited mechanisms of susceptibility has been unknown. We have used the methods of population genetics in the mouse to discover a single dominant autosomal gene which controls the susceptibility to tuberculosis. The...
Topics
- Animals
- Cattle
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Disease Models, Animal
- Disease Susceptibility
- Genetic Predisposition to Disease
- Genetics, Population
- Humans
- Mice
- Molecular Biology