Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis.

Abstract excerpt

In humans, genetic factors have long been suspected to contribute to the onset and outcome of tuberculosis. Such effects are difficult to identify owing to their complex inheritance, and to the confounding impact of environmental factors, notably pathogen-associated virulence determinants. Recently, forward genetic approaches in mouse models and in human populations have been used to elucidate a molecular basis...

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