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Article

Silencing mi<scp>R</scp>‐146a influences <scp>B</scp> cells and ameliorates experimental autoimmune myasthenia gravis

24 Jun 2014

Abstract excerpt

MicroRNAs have been shown to be important regulators of immune homeostasis as patients with aberrant microRNA expression appeared to be more susceptible to autoimmune diseases. We recently found that miR-146a was up-regulated in activated B cells in response to rat acetylcholine receptor (AChR) α-subunit 97-116 peptide, and this up-regulation was significantly attenuated by AntagomiR-146a. Our data also...

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PMID: 24962817
DOI: 10.1111/imm.12347

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