Article
Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients.
Biochemical and biophysical research communications - 18 Jul 2014
Ali Mohamed A E, Naka Kazuhito, Yoshida Akiyo, Fuse Kyoko, Kasada Atsuo, Hoshii Takayuki, Tadokoro Yuko, Ueno Masaya, Ohta Kumiko, Kobayashi Masahiko, Takahashi Chiaki, Hirao Atsushi
Abstract excerpt
Acute myeloid leukaemia (AML) is a heterogeneous neoplastic disorder in which a subset of cells function as leukaemia-initiating cells (LICs). In this study, we prospectively evaluated the leukaemia-initiating capacity of AML cells fractionated according to the expression of a nucleolar GTP binding protein, nucleostemin (NS). To monitor NS expression in living AML cells, we generated a mouse AML model in which...
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