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Article

Maintenance of tumor initiating cells of defined genetic composition by nucleostemin

5 Jul 2011

Abstract excerpt

Recent work has identified a subset of cells resident in tumors that exhibit properties similar to those found in normal stem cells. Such cells are highly tumorigenic and may be involved in resistance to treatment. However, the genes that regulate the tumor initiating cell (TIC) state are unknown. Here, we show that overexpression of either of the nucleolar GTP-binding proteins nucleostemin (NS) or GNL3L drives...

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PMID: 21730156
DOI: 10.1073/pnas.1015171108

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