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Article

Tumor-Initiating Function of Nucleostemin-Enriched Mammary Tumor Cells

7 Nov 2010

Abstract excerpt

Nucleostemin (NS) is highly expressed in normal stem cells and tumors and is upregulated by estradiol in MCF7 breast cancer cells. To investigate the role of NS in mammary tumorigenesis, we established first that NS is expressed at higher levels in the basal cell type than in the luminal cell type in mouse mammary tumors and human breast cancer cells. NS expression was also increased during progression of mammary...

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PMID: 21045149
DOI: 10.1158/0008-5472.can-10-2159

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