Article
Impaired natural killer cell responses are associated with loss of the highly activated NKG2A(+)CD57(+)CD56(dim) subset in HIV-1 subtype D infection in Uganda.
AIDS (London, England) - 1 Jun 2014
Naluyima Prossy, Eller Michael A, Laeyendecker Oliver, Quinn Thomas C, Serwadda David, Sewankambo Nelson K, Gray Ronald H, Michael Nelson L, Wabwire-Mangen Fred, Robb Merlin L, Sandberg Johan K
Abstract excerpt
OBJECTIVE: Of the predominant HIV-1 subtypes in Uganda, subtype D infection confers a worse prognosis. HIV-1 infection causes perturbations to natural killer (NK) cells, and yet these cells can exert immune pressure on the virus and influence clinical outcome. Here, we studied NK cell activation and function in Ugandans with chronic untreated HIV-1 subtype D infection in comparison to uninfected community matched...
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