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Article

Chimeric Avidin--NMR structure and dynamics of a 56 kDa homotetrameric thermostable protein.

PloS one - 1 Jan 2014

Tossavainen Helena, Kukkurainen Sampo, Määttä Juha A E, Kähkönen Niklas, Pihlajamaa Tero, Hytönen Vesa P, Kulomaa Markku S, Permi Perttu

Abstract excerpt

Chimeric avidin (ChiAVD) is a product of rational protein engineering remarkably resistant to heat and harsh conditions. In quest of the fundamentals behind factors affecting stability we have elucidated the solution NMR spectroscopic structure of the biotin-bound form of ChiAVD and characterized the protein dynamics through 15N relaxation and hydrogen/deuterium (H/D) exchange of this and the biotin-free form. To...

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Identifiers

PMID: 24959850
DOI: 10.1371/journal.pone.0100564
PMCID: PMC4069078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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