Article
Slow motions in the hydrophobic core of chicken villin headpiece subdomain and their contributions to configurational entropy and heat capacity from solid-state deuteron NMR measurements.
Biochemistry - 13 Dec 2011
Vugmeyster Liliya, Ostrovsky Dmitry, Khadjinova Anastasia, Ellden Jeremy, Hoatson Gina L, Vold Robert L
Abstract excerpt
We have investigated microsecond to millisecond time scale dynamics in several key hydrophobic core methyl groups of chicken villin headpiece subdomain protein (HP36) using a combination of single-site labeling, deuteron solid-state NMR line shape analysis, and computational modeling. Deuteron line shapes of hydrated powder samples are dominated by rotameric jumps and show a large variability of rate constants,...
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