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Article

Controlling quaternary structure assembly: subunit interface engineering and crystal structure of dual chain avidin.

Journal of molecular biology - 23 Jun 2006

Hytönen Vesa P, Hörhä Jarno, Airenne Tomi T, Niskanen Einari A, Helttunen Kaisa J, Johnson Mark S, Salminen Tiina A, Kulomaa Markku S, Nordlund Henri R

Abstract excerpt

Dual chain avidin (dcAvd) is an engineered avidin form, in which two circularly permuted chicken avidin monomers are fused into one polypeptide chain. DcAvd can theoretically form two different pseudotetrameric quaternary assemblies because of symmetry at the monomer-monomer interfaces. Here, our aim was to control the assembly of the quaternary structure of dcAvd. We introduced the mutation I117C into one of the...

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Identifiers

PMID: 16787776
DOI: 10.1016/j.jmb.2006.04.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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