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Article

Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG.

Bone - 1 Sept 2014

Zhai Yuan-Kun, Guo Xiao-Yu, Ge Bao-Feng, Zhen Ping, Ma Xiao-Ni, Zhou Jian, Ma Hui-Ping, Xian Cory J, Chen Ke-Ming

Abstract excerpt

Icariin, a prenylated flavonol glycoside isolated from Epimedii herba, has been found to be a potent stimulator of osteogenic differentiation and has potential application in preventing bone loss. However, the signaling pathway underlying its osteogenic effect remains unclear. We hypothesized that the osteogenic activity of icariin is related to the nitric oxide (NO) signal pathway and PI3K/AKT pathway in its...

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PMID: 24956021
DOI: 10.1016/j.bone.2014.06.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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