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Article

Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study.

PloS one - 1 Jan 2012

Yao Dong, Xie Xin-Hui, Wang Xin-Luan, Wan Chao, Lee Yuk-Wai, Chen Shi-Hui, Pei Duan-Qing, Wang Yi-Xiang, Li Gang, Qin Ling

Abstract excerpt

We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation of mesenchymal stem cells (MSCs) only under osteogenic induction conditions. We also demonstrated its effect on inhibition of adipogenic differentiation of MSCs. Unlike the...

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Source

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Identifiers

PMID: 22952579
DOI: 10.1371/journal.pone.0041264
PMCID: PMC3431393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22952579-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study.PMID 22952579Read ↗

Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG.Semantic proximity Read ↗

Epimedium/Icariin promotes angiogenesis through HIF-1 signaling pathwaySemantic proximity Read ↗

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Icariin stimulates osteogenic differentiation of rat bone marrow stromal stem cells by increasing TAZ expression.Semantic proximity Read ↗

Calycosin-7-O-β-Glucoside Isolated from Astragalus membranaceus Promotes Osteogenesis and Mineralization in Human Mesenchymal Stem CellsSemantic proximity Read ↗

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