Similarities and differences between the effects of ipriflavone and vitamin K on bone resorption and formation in vitro.

doi:10.1016/8756-3282(94)00046-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Similarities and differences between the effects of ipriflavone and vitamin K on bone resorption and formation in vitro.

Bone - 1 Apr 1995

Notoya K, Yoshida K, Shirakawa Y, Taketomi S, Tsuda M

Abstract excerpt

The effects of ipriflavone and vitamin K on bone metabolism were examined using a culture system. Vitamin K1 and vitamin K2 (10(-7)M-10(-5)M) inhibited both the activation of mature osteoclasts and the formation of new osteoclasts without affecting the growth of progenitor cells in cultures of mouse unfractionated bone cells. The inhibitory effects of vitamin K on bone resorption were similar to those of...

Topics

Acid Phosphatase
Animals
Bone Development
Bone Marrow
Bone Resorption
Cell Division
Cell Fractionation
Cells, Cultured
Drug Synergism
Femur
Isoflavones
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Culture Techniques

Osteoclasts

Phenotype

Rats

Stem Cells

Stromal Cells

Source

Open in PubMed

Identifiers

PMID: 7626324
DOI: 10.1016/8756-3282(94)00046-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7626324-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Similarities and differences between the effects of ipriflavone and vitamin K on bone resorption and formation in vitro.PMID 7626324Read ↗

Effect of ipriflavone on expression of markers characteristic of the osteoblast phenotype in rat bone marrow stromal cell culture.Semantic proximity Read ↗

Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms.Semantic proximity Read ↗

Ipriflavone influences the osteoblastic phenotype in vitro.Semantic proximity Read ↗

Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG.Semantic proximity Read ↗

The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitroSemantic proximity Read ↗

Inhibitory effect of zinc compounds on osteoclast-like cell formation in mouse marrow culturesSemantic proximity Read ↗

Small molecule inhibitors of IκB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy‐induced bone loss in vivoSemantic proximity Read ↗

Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

Protein phosphatase inhibitors, okadaic acid and calyculin A, induce alkaline phosphatase activity in osteoblastic cells derived from newborn mouse calvaria.Semantic proximity Read ↗

Cholera toxin and forskolin stimulate formation of osteoclast-like cells in mouse marrow cultures and cultured mouse calvarial bones.Semantic proximity Read ↗

Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.