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Article

Icariin stimulates osteogenic differentiation of rat bone marrow stromal stem cells by increasing TAZ expression.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2017

Wei QiuShi, He MinCong, Chen MeiHui, Chen ZhenQiu, Yang Fan, Wang HaiBin, Zhang Jin, He Wei

Abstract excerpt

Icariin, the major ingredient of Herba Epimedii, promotes the osteogenic differentiation of rat bone marrow stromal cells (rBMSCs) and exerts protective effects against bone loss and increases bone regeneration, but the underlying signaling pathway by which icariin affects osteogenic differentiation remain unclear. Transcriptional coactivator with PDZ-binding motif (TAZ) is a transcriptional modulator of the...

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Identifiers

PMID: 28486190
DOI: 10.1016/j.biopha.2017.04.019

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DKK1

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