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Article

Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERα-Wnt/β-catenin signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2016

Wei QiuShi, Zhang Jin, Hong GuoJu, Chen ZhenQiu, Deng WeiMin, He Wei, Chen Mei Hui

Abstract excerpt

Icariin, the main effective component of Herba Epimedii, has been identified to regulate the osteogenic differentiation of rat bone marrow stromal cells (rBMSCs) and have potential application in preventing bone loss and promoting bone regeneration. However, the underlying signaling pathway of its osteogenic effect remains unclear. Here, we investigated whether icariin could promote osteogenesis of rBMSCs through...

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Source

Identifiers

PMID: 27764755
DOI: 10.1016/j.biopha.2016.09.107

Genes

DKK1
DLX5
TCF7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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