Article
Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke.
Head & neck - 1 Nov 2015
Li Ryan, Faden Daniel L, Fakhry Carole, Langelier Chaz, Jiao Yuchen, Wang Yuxuan, Wilkerson Matthew D, Pedamallu Chandra Sekhar, Old Matthew, Lang James, Loyo Myriam, Ahn Sun Mi, Tan Marietta, Gooi Zhen, Chan Jason, Richmon Jeremy, Wood Laura D, Hruban Ralph H, Bishop Justin, Westra William H, Chung Christine H, Califano Joseph, Gourin Christine G, Bettegowda Chetan, Meyerson Matthew, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, DeRisi Joseph L, Koch Wayne M, Agrawal Nishant
Abstract excerpt
BACKGROUND: Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use. METHODS: We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared to previously sequenced cases. RNA from 20 tumors was evaluated by massively parallel sequencing to search for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.