Article

Liver Disease Reveals KIF12 as a Critical Regulator of Mitochondria, Lysosome and Cilia Localization

2026-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Pathogenic variants in kinesin family member 12 (KIF12) cause pediatric liver disease, yet the cellular mechanisms underlying this phenotype remain unknown. Here we show that KIF12 expression in the healthy human liver is primarily detected in biliary epithelial cells, as revealed by single cell RNA-sequencing data. To investigate its role in biliary pathology, we introduced a homozygous KIF12...

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Literature Corpus work: a262bd75-8a2f-5da8-94b3-dbd25e7efef2
DOI: 10.64898/2026.02.24.707575

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