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Article

Arl3 and RP2 regulate the trafficking of ciliary tip kinesins

20 Apr 2017

Abstract excerpt

Ciliary trafficking defects are the underlying cause of many ciliopathies, including Retinitis Pigmentosa (RP). Anterograde intraflagellar transport (IFT) is mediated by kinesin motor proteins; however, the function of the homodimeric Kif17 motor in cilia is poorly understood, whereas Kif7 is known to play an important role in stabilizing cilia tips. Here we identified the ciliary tip kinesins Kif7 and Kif17 as...

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PMID: 28444310
DOI: 10.1093/hmg/ddx143

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