Article
Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
Human molecular genetics - 15 Nov 2014
Liao Jiemin, Su Xinyi, Chen Peng, Wang Xu, Xu Liang, Li Xiang, Thean Lennard, Tan Clement, Tan Ava G, Tay Wan-Ting, Jun Gyungah, Zheng Yingfeng, Chew Merwyn, Wang Ya Xing, Tan Queenie S, Barathi Veluchamy A, Klein Barbara E, Saw Seang-Mei, Vithana Eranga N, Tai E-Shyong, Iyengar Sudha K, Mitchell Paul, Khor Chiea-Chuen, Aung Tin, Wang Jie Jin, Jonas Jost B, Teo Yik-Ying, Wong Tien Yin, Cheng Ching-Yu
Abstract excerpt
Age-related cataract is a leading cause of blindness worldwide, especially in developing countries where access to cataract surgery remains limited. Previous linkage and candidate gene studies suggested genetic influences on age-related nuclear cataract but few genetic markers have been identified thus far. We conducted genome-wide association studies on 4569 Asians (including 2369 Malays and 2200 Indians), and...
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