Article
A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.
Nature communications - 14 Jun 2021
Choquet Hélène, Melles Ronald B, Anand Deepti, Yin Jie, Cuellar-Partida Gabriel, Wang Wei, Hoffmann Thomas J, Nair K Saidas, Hysi Pirro G, Lachke Salil A, Jorgenson Eric
Abstract excerpt
Cataract is the leading cause of blindness among the elderly worldwide and cataract surgery is one of the most common operations performed in the United States. As the genetic etiology of cataract formation remains unclear, we conducted a multiethnic genome-wide association meta-analysis, combining results from the GERA and UK Biobank cohorts, and tested for replication in the 23andMe research cohort. We report...
Topics
- Aging
- Animals
- Caspase 7
- Cataract
- Cohort Studies
- Disease Models, Animal
- Gene Expression Regulation
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Lens, Crystalline
- Logistic Models