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Article

FOXO1 binds to the TAU5 motif and inhibits constitutively active androgen receptor splice variants

6 Feb 2013

Abstract excerpt

BACKGROUND: Aberrant activation of the androgen receptor (AR) is a major factor highly relevant to castration-resistant progression of prostate cancer (PCa). FOXO1, a key downstream effector of PTEN, inhibits androgen-independent activation of the AR. However, the underlying mechanism remains elusive. METHODS: The inhibitory effect of FOXO1 on full-length and constitutively active splice variants of the AR was...

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PMID: 23389878
DOI: 10.1002/pros.22649

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