Article
Snail cooperates with Kras G12D in vivo to increase stem cell factor and enhance mast cell infiltration.
Molecular cancer research : MCR - 1 Oct 2014
Knab Lawrence M, Ebine Kazumi, Chow Christina R, Raza Sania S, Sahai Vaibhav, Patel Akash P, Kumar Krishan, Bentrem David J, Grippo Paul J, Munshi Hidayatullah G
Abstract excerpt
UNLABELLED: Pancreatic ductal adenocarcinoma (PDAC) is associated with a pronounced fibro-inflammatory stromal reaction that contributes to tumor progression. A critical step in invasion and metastasis is the epithelial-to-mesenchymal transition (EMT), which can be regulated by the Snail family of transcription factors. Overexpression of Snail (Snai1) and mutant Kras(G12D) in the pancreas of transgenic mice,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.