Article
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
Molecular psychiatry - 1 Sept 2012
Bergen S E, O'Dushlaine C T, Ripke S, Lee P H, Ruderfer D M, Akterin S, Moran J L, Chambert K D, Handsaker R E, Backlund L, Ösby U, McCarroll S, Landen M, Scolnick E M, Magnusson P K E, Lichtenstein P, Hultman C M, Purcell S M, Sklar P, Sullivan P F
Abstract excerpt
Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders with overlapping susceptibility loci and symptomatology. We conducted a genome-wide association study (GWAS) of these disorders in a large Swedish sample. We report a new and independent case-control analysis of 1507 SCZ cases, 836 BD cases and 2093 controls. No single-nucleotide polymorphisms (SNPs) achieved significance in...
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