Article
Common variants on chromosome 6p22.1 are associated with schizophrenia.
Nature - 6 Aug 2009
Shi Jianxin, Levinson Douglas F, Duan Jubao, Sanders Alan R, Zheng Yonglan, Pe'er Itsik, Dudbridge Frank, Holmans Peter A, Whittemore Alice S, Mowry Bryan J, Olincy Ann, Amin Farooq, Cloninger C Robert, Silverman Jeremy M, Buccola Nancy G, Byerley William F, Black Donald W, Crowe Raymond R, Oksenberg Jorge R, Mirel Daniel B, Kendler Kenneth S, Freedman Robert, Gejman Pablo V
Abstract excerpt
Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5-1%, with high heritability (80-85%) and complex transmission. Recent studies implicate rare, large, high-penetrance copy number variants in some cases, but the genes or biological mechanisms that underlie susceptibility are not known. Here we show that schizophrenia is significantly associated with single nucleotide polymorphisms (SNPs) in...
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