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Article

Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation.

Development (Cambridge, England) - 1 Apr 2009

Pryce Brian A, Watson Spencer S, Murchison Nicholas D, Staverosky Julia A, Dünker Nicole, Schweitzer Ronen

Abstract excerpt

Tendons and ligaments mediate the attachment of muscle to bone and of bone to bone to provide connectivity and structural integrity in the musculoskeletal system. We show that TGFbeta signaling plays a major role in the formation of these tissues. TGFbeta signaling is a potent inducer of the tendon progenitor (TNP) marker scleraxis both in organ culture and in cultured cells, and disruption of TGFbeta signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19304887
DOI: 10.1242/dev.027342
PMCID: PMC2687466

Genes

TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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