Article
Knockdown of col22a1 gene in zebrafish induces a muscular dystrophy by disruption of the myotendinous junction.
Development (Cambridge, England) - 1 Nov 2013
Charvet Benjamin, Guiraud Alexandre, Malbouyres Marilyne, Zwolanek Daniela, Guillon Emilie, Bretaud Sandrine, Monnot Catherine, Schulze Jörg, Bader Hannah L, Allard Bruno, Koch Manuel, Ruggiero Florence
Abstract excerpt
The myotendinous junction (MTJ) is the major site of force transfer in skeletal muscle, and defects in its structure correlate with a subset of muscular dystrophies. Col22a1 encodes the MTJ component collagen XXII, the function of which remains unknown. Here, we have cloned and characterized the zebrafish col22a1 gene and conducted morpholino-based loss-of-function studies in developing embryos. We showed that...
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