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Article

Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS.

Orphanet journal of rare diseases - 16 Jun 2014

Bendikov-Bar Inna, Rapaport Debora, Larisch Sarit, Horowitz Mia

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is a movement neurodegenerative disorder characterized by death of dopaminergic neurons in the substantia nigra pars compacta of the brain that leads to movement impairments including bradykinesia, resting tremor, postural instability and rigidity. Mutations i...

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Identifiers

PMID: 24935484
DOI: 10.1186/1750-1172-9-86
PMCID: PMC4074407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24935484-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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