Article
Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.
Human molecular genetics - 15 Aug 2016
Magalhaes Joana, Gegg Matthew E, Migdalska-Richards Anna, Doherty Mary K, Whitfield Phillip D, Schapira Anthony H V
Abstract excerpt
Glucocerebrosidase (GBA1) gene mutations increase the risk of Parkinson disease (PD). While the cellular mechanisms associating GBA1 mutations and PD are unknown, loss of the glucocerebrosidase enzyme (GCase) activity, inhibition of autophagy and increased α-synuclein levels have been implicated. Here we show that autophagy lysosomal reformation (ALR) is compromised in cells lacking functional GCase. ALR is a...
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