Article
A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2022
Deen Matthew C, Zhu Yanping, Gros Christina, Na Na, Gilormini Pierre-André, Shen David L, Bhosale Sandeep, Anastasi Nadia, Wang RuiQi, Shan Xiaoyang, Harde Eva, Jagasia Ravi, Lynn Francis C, Vocadlo David J
Abstract excerpt
Loss of activity of the lysosomal glycosidase β-glucocerebrosidase (GCase) causes the lysosomal storage disease Gaucher disease (GD) and has emerged as the greatest genetic risk factor for the development of both Parkinson disease (PD) and dementia with Lewy bodies. There is significant interest into how GCase dysfunction contributes to these diseases, however, progress toward a full understanding is complicated...
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