Article
Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.
Human molecular genetics - 15 Nov 2014
Ramos Adriana, Rodríguez-Seoane Carmen, Rosa Isaac, Trossbach Svenja V, Ortega-Alonso Alfredo, Tomppo Liisa, Ekelund Jesper, Veijola Juha, Järvelin Marjo-Riitta, Alonso Jana, Veiga Sonia, Sawa Akira, Hennah William, García Angel, Korth Carsten, Requena Jesús R
Abstract excerpt
In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions. Thus, study of DISC1 may provide a clue to understand the biology of major mental illness. A neuropeptide precursor VGF has potent antidepressant effects and has been reportedly associated with bipolar disorder. Here we show that DISC1 knockdown leads to a...
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