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Article

Mutation analysis of the EGFR gene and its downstream signaling pathway in thymic carcinoma patients from a Chinese Han population.

The clinical respiratory journal - 1 Feb 2018

Zhan Ping, Chen Xiao, Wu Xiao-Yuan, Hou Zhi-Bo, Qian Qian, Zhang Yu, Zou Jue, Zhang Yuan-Qing, Wan Ming-Yue, Wang Jian-Dong, Yu Li-Ke, Xie Hai-Yan

Abstract excerpt

INTRODUCTION: For thymic carcinoma (TC), which is a rare epithelial neoplasm of the thymus gland, median survival with current treatments is only 2 years. OBJECTIVES: Mutations in the epidermal growth factor receptor (EGFR) gene or its downstream effectors may cause constitutive activation that leads to cell proliferation and metastases. Thus, molecular profiling is essential for selecting TC patients who may...

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Identifiers

PMID: 27731926
DOI: 10.1111/crj.12569

Genes

EGFR
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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