Article
Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.
Cancer discovery - 1 Sept 2014
Al-Ahmadie Hikmat, Iyer Gopa, Hohl Marcel, Asthana Saurabh, Inagaki Akiko, Schultz Nikolaus, Hanrahan Aphrothiti J, Scott Sasinya N, Brannon A Rose, McDermott Gregory C, Pirun Mono, Ostrovnaya Irina, Kim Philip, Socci Nicholas D, Viale Agnes, Schwartz Gary K, Reuter Victor, Bochner Bernard H, Rosenberg Jonathan E, Bajorin Dean F, Berger Michael F, Petrini John H J, Solit David B, Taylor Barry S
Abstract excerpt
UNLABELLED: Metastatic solid tumors are almost invariably fatal. Patients with disseminated small-cell cancers have a particularly unfavorable prognosis, with most succumbing to their disease within two years. Here, we report on the genetic and functional analysis of an outlier curative response...
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