Identification of TMC1 as a relatively common cause for nonsyndromic hearing loss in the Saudi population.

doi:10.1002/ajmg.b.32774

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Identification of TMC1 as a relatively common cause for nonsyndromic hearing loss in the Saudi population.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2020

Ramzan Khushnooda, Al-Owain Mohammed, Al-Numair Nouf S, Afzal Sibtain, Al-Ageel Sarah, Al-Amer Sultan, Al-Baik Lina, Al-Otaibi Ghoson F, Hashem Amal, Al-Mashharawi Eman, Basit Sulman, Al-Mazroea Abdal H, Softah Ameen, Sogaty Sameera, Imtiaz Faiqa

Abstract excerpt

Hearing loss (HL) is the most common sensory disorder worldwide and genetic factors contribute to approximately half of congenital HL cases. HL is subject to extensive genetic heterogeneity, rendering molecular diagnosis difficult. Mutations of the transmembrane channel-like 1 (TMC1) gene cause hearing defects in humans and mice. The precise function of TMC1 protein in the inner ear is unknown, although it is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ear, Inner

Share to Exons

Share to Family Health

Share to Genetic Linkage

Share to Hearing Loss, Sensorineural

Share to Linkage Disequilibrium

Share to Saudi Arabia

Source

Open in PubMed

Identifiers

PMID: 31854501
DOI: 10.1002/ajmg.b.32774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of TMC1 as a relatively common cause for nonsyndromic hearing loss in the Saudi population.PMID 31854501Read ↗

Genetic and clinical aspects of TMC1-related hearing loss in Iranian families: identification of two novel variants.Semantic proximity Read ↗

Heterozygous variants in transmembrane channel-like 1 gene cause autosomal recessive nonsyndromic hearing loss.Semantic proximity Read ↗

A TMC1 (transmembrane channel-like 1) mutation (p.S320R) in a Polish family with hearing impairment.Semantic proximity Read ↗

A novel mutation in the TMC1 gene causes non-syndromic hearing loss in a Moroccan family.Semantic proximity Read ↗

Novel homozygous variants in the TMC1 and CDH23 genes cause autosomal recessive nonsyndromic hearing loss.Semantic proximity Read ↗

Identification of a novel homozygous mutation in transmembrane channel like 1 (TMC1) gene, one of the second-tier hearing loss genes after GJB2 in India.Semantic proximity Read ↗

Exome sequencing identifies a mutation in TMC1 as a novel cause of autosomal recessive nonsyndromic hearing loss.Semantic proximity Read ↗

Prevalence and clinical features of autosomal dominant and recessive TMC1-associated hearing loss.Semantic proximity Read ↗

[Advances in hereditary hearing loss caused by TMC1 mutations].Semantic proximity Read ↗

Genetic causes of nonsyndromic hearing loss in Iran in comparison with other populations.Semantic proximity Read ↗

Mutations in TMC1 contribute significantly to nonsyndromic autosomal recessive sensorineural hearing loss: a report of five novel mutations.Semantic proximity Read ↗

Autosomal recessive non-syndromic hearing loss is caused by novel compound heterozygous mutations in TMC1 from a Tibetan Chinese family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.