Article
Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2005
Leibovici Dan, Grossman H Barton, Dinney Colin P, Millikan Randal E, Lerner Seth, Wang Yunfei, Gu Jian, Dong Qiong, Wu Xifeng
Abstract excerpt
PURPOSE: Since chronic inflammation contributes to tumorigenesis, we hypothesized that the risk and clinical outcome of bladder cancer (BC) might be modulated by genetic variations in inflammation genes. METHODS: Using the TaqMan method, we genotyped single nucleotide polymorphisms in interleukin (IL) -6 (-174 G-->C), IL-8 (-251 T-->A), tumor necrosis factor-alpha (TNF-alpha; -308 G-->A), and peroxisome...
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