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Article

OmrA sRNA inhibits translation of phosphoenolpyruvate carboxylase to impair TCA-cycle flux.

Nucleic acids research - 10 Aug 2026

Stenum Thomas, Le Huyen Kim Boi, Kjellin Jonas, Koskiniemi Sanna, Wagner E Gerhart H, Holmqvist Erik

Abstract excerpt

Small RNAs (sRNAs) rarely cause strong growth phenotypes upon overexpression, complicating efforts to link regulatory interactions to physiological outcomes. Here, we report that high levels of the Escherichia coli sRNA OmrA, but not its sibling OmrB, severely inhibit growth in glucose minimal medium. Genetic, biochemical, and physiological analyses indicate that OmrA-dependent toxicity results from reduced flux...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42598858
DOI: 10.1093/nar/gkag804
PMCID: PMC13473878

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