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Article

ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status.

Cytometry. Part B, Clinical cytometry - 1 Jul 2014

Wiggers Tom G H, Westra Guus, Westers Theresia M, Abbes Andre P, Strunk Annuska, Kuiper-Kramer Ellen, Poddighe Pino, van de Loosdrecht Arjan A, Chamuleau Martine E D

Abstract excerpt

The strongest prognostic factor in chronic B-cell lymphocytic leukemia (CLL) is the mutational status of the immunoglobulin heavy chain variable region (IGHV) genes. Determination of this mutational status is laborious and therefore not applied in routine diagnostics. A search for "surrogate mark...

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Source

Identifiers

PMID: 24924909
DOI: 10.1002/cyto.b.21132

Genes

ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24924909-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status.PMID 24924909Read ↗

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MFI ratio estimation of ZAP-70 in B-CLL by flow cytometry can be improved by considering the isotype-matched antibody signal.Semantic proximity Read ↗

COBLL1, LPL and ZAP70 expression defines prognostic subgroups of chronic lymphocytic leukemia patients with high accuracy and correlates with IGHV mutational status.Semantic proximity Read ↗

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Quantification of ZAP70 mRNA in B cells by real-time PCR is a powerful prognostic factor in chronic lymphocytic leukemia.Semantic proximity Read ↗

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