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Article

ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status.

Cytometry. Part B, Clinical cytometry - 1 Jul 2014

Wiggers Tom G H, Westra Guus, Westers Theresia M, Abbes Andre P, Strunk Annuska, Kuiper-Kramer Ellen, Poddighe Pino, van de Loosdrecht Arjan A, Chamuleau Martine E D

Abstract excerpt

The strongest prognostic factor in chronic B-cell lymphocytic leukemia (CLL) is the mutational status of the immunoglobulin heavy chain variable region (IGHV) genes. Determination of this mutational status is laborious and therefore not applied in routine diagnostics. A search for "surrogate markers" has been conducted over the past few years. One of the most promising surrogate markers is ZAP70, but...

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Identifiers

PMID: 24924909
DOI: 10.1002/cyto.b.21132

Genes

ZAP70

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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