Article
Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts.
Cell research - 1 Nov 2011
Ge Xiaojia, McFarlane Craig, Vajjala Anuradha, Lokireddy Sudarsanareddy, Ng Zhi Hui, Tan Chek Kun, Tan Nguan Soon, Wahli Walter, Sharma Mridula, Kambadur Ravi
Abstract excerpt
TGF-β and myostatin are the two most important regulators of muscle growth. Both growth factors have been shown to signal through a Smad3-dependent pathway. However to date, the role of Smad3 in muscle growth and differentiation is not investigated. Here, we demonstrate that Smad3-null mice have decreased muscle mass and pronounced skeletal muscle atrophy. Consistent with this, we also find increased protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.