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Article

Molecular mechanisms for the p38-induced cellular senescence in normal human fibroblast

10 Jun 2014

Abstract excerpt

We previously reported that TAK1, one of the mitogen-activated protein kinase kinase kinases (MAP3Ks), represses the transcription of the human telomerase reverse transcriptase (hTERT) gene in human cancer cells and induces cellular senescence in normal diploid human cells. On the basis of these results, we presumed a link between hTERT repression and the induction of cellular senescence. In this study, we...

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PMID: 24920674
DOI: 10.1093/jb/mvu040

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