Identification of p38^MAPK‐dependent genes with changed transcript abundance in H₂O₂‐induced premature senescence of IMR‐90 hTERT human fibroblasts

Abstract excerpt

Premature senescence of IMR-90 human diploid fibroblasts expressing telomerase (hTERT) establishes after exposure to an acute sublethal concentration of H2O2. We showed herein that p38(MAPK) was phosphorylated after exposure of IMR-90 hTERT cells to H2O2. Selective inhibition of p38(MAPK) activity attenuated the increase in the proportion of cells positive for senescence associated beta-galactosidase activity. We...

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