Article
Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases.
PloS one - 1 Jan 2014
Malik Deepika, Hsu Tiffany, Falatoonzadeh Payam, Cáceres-del-Carpio Javier, Tarek Mohamed, Chwa Marilyn, Atilano Shari R, Ramirez Claudio, Nesburn Anthony B, Boyer David S, Kuppermann Baruch D, Jazwinski S Michal, Miceli Michael V, Wallace Douglas C, Udar Nitin, Kenney M Cristina
Abstract excerpt
BACKGROUND: It has been recognized that cells do not respond equally to ultraviolet (UV) radiation but it is not clear whether this is due to genetic, biochemical or structural differences of the cells. We have a novel cybrid (cytoplasmic hybrids) model that allows us to analyze the contribution of mitochondrial DNA (mtDNA) to cellular response after exposure to sub-lethal dose of UV. mtDNA can be classified into...
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