Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy.

doi:10.1016/s0925-4439(02)00097-2

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Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy.

Biochimica et biophysica acta - 9 Oct 2002

Carelli Valerio, Vergani Lodovica, Bernazzi Barbara, Zampieron Claudia, Bucchi Laura, Valentino Maria, Rengo Chiara, Torroni Antonio, Martinuzzi Andrea

Abstract excerpt

The possibility that some combinations of mtDNA polymorphisms, previously associated with Leber's hereditary optic neuropathy (LHON), may affect mitochondrial respiratory function was tested in osteosarcoma-derived transmitochondrial cytoplasmic hybrids (cybrids). In this cellular system, in the presence of the same nuclear background, different exogenous mtDNAs are used to repopulate a parental cell line...

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Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy.

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Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy.

Abstract excerpt

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